منابع مشابه
The Comprehensive Sourcebook of Bacterial Protein Toxins
A significant number of bacteria, including the emerging multidrug-resistant “superbugs,” such as Pseudomonas aeruginosa, Clostridium difficile, Staphylococcus aureus, and Escherichia coli, secrete highly potent exotoxins with no antitoxins currently available to disable them. Several bacterial toxins, such as the botulinum neurotoxin (BoNT) of Clostridium botulinum, can be aerosolized and used...
متن کاملBacterial toxins.
Many bacterial toxins are proteins, encoded by the bacterial chromosomal genes, plasmids or phages. Lysogenic phages form part of the chromosome. The toxins are usually liberated from the organism by lysis, but some are shed with outer membrane proteins in outer membrane vesicles. An important non-protein toxin is lipopolysaccharide or endotoxin, which is a constituent of the cell wall of gram ...
متن کاملSite specific protein O-glucosylation with bacterial toxins.
Using a MALDI-MS based assay, the kinetic parameters for peptide glucosylation using the C. difficile toxin B glycosyltransferase domain were determined. The minimum consensus sequence for glucosylation was YXXTXFXXY and the optimal peptide found was YAPTVFDAY. Using this sequence, homogenous glucosylated proteins could be readily produced.
متن کاملGeneral aspects and recent advances on bacterial protein toxins.
Bacterial pathogens produce protein toxins to influence host-pathogen interactions and tip the outcome of these encounters toward the benefit of the pathogen. Protein toxins modify host-specific targets through posttranslational modifications (PTMs) or noncovalent interactions that may inhibit or activate host cell physiology to benefit the pathogen. Recent advances have identified new PTMs and...
متن کاملInositol Hexakisphosphate-Induced Autoprocessing of Large Bacterial Protein Toxins
Large bacterial protein toxins autotranslocate functional effector domains to the eukaryotic cell cytosol, resulting in alterations to cellular functions that ultimately benefit the infecting pathogen. Among these toxins, the clostridial glucosylating toxins (CGTs) produced by Gram-positive bacteria and the multifunctional-autoprocessing RTX (MARTX) toxins of Gram-negative bacteria have distinc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Revista Brasileira de Ciências Farmacêuticas
سال: 2004
ISSN: 1516-9332
DOI: 10.1590/s1516-93322004000200023